Cardiovascular
The American Society of Interventional Pain Physicians (ASIPP) announced they have released the 2009 updated Interventional Pain Management (IPM) guidelines.
When doctors are managing care for women with breast cancer, the information available to them profoundly influences the type of care they recommend. Knowing whether a woman"s cancer has metastasized, for instance, directly affects how her doctors will approach treatment -- which may in turn influence the outcome of that treatment.
Want to find an asthma education centre or a chronic obstructive pulmonary disease (COPD) clinic near you? Need to get a lung function test and don"t know where to go?
Global health experts have moved use of sunbeds and exposure to ultraviolet radiation (including sun exposure) to the highest risk category for causing cancer: they
"No matter what form of health care reform emerges from the current debates and discussion," Congress should include a "provision to the legislation to permanently exclude abortion from taxpayer-funded health care or health insurance," Family Research Council President Tony Perkins writes in a Politico opinion piece. Although some argue that the government "cannot or should not restrict benefits when it purchases insurance, the same way it does when reimbursing directly for medical procedures," that argument "already failed when it came up in the 1990s in the context of Medicaid managed care plans," Perkins writes, adding that the Hyde Amendment was "revised to cover them, as well." There also are arguments in Congress that "if people can opt for private health insurance that funds abortion and receive a tax break for their purchase of such insurance, then poor people dependent on direct government payments for their health insurance cannot be denied similar coverage," according to Perkins. However, "this presumes that there is no difference between what people may do with their own money and what they may do with the taxpayers" money," Perkins writes, adding that such an argument "makes sense only if we assume it"s all the government"s money in the end" (Perkins, Politico, 7/28).
The following summarizes selected women"s health-related blog entries. ~ "Mainstream Media Reinforces Unexamined Arguments Against Public Funding for Abortion," Amanda Marcotte, RH Reality Check: It "seems that mainstream media s ... believe that abortion is an effective cudgel to beat health care reform to death," Marcotte writes. According to Marcotte, the "unvarnished truth" is that there is "no way that any kind of public health care plan will have elective abortion coverage. Nor is there any real chance of abortion becoming mandated coverage." However, "you wouldn"t know it to read the media coverage of this issue," she writes, continuing that "we"ve got the toxic mixture of pants-on-fire lying anti-choicers and cowardly media outlets that give the opponents of health care reform an opportunity to lie about the potential for taxpayer-funded abortions." Those who defend health care reform are "so busy trying to shut down the misinformation about abortion coverage that we"re not having the more interesting discussion about whether or not abortion should be covered," Marcotte says. She adds, "And by not having that discussion, we"re allowing the belief that some people"s moral objections to abortion should dictate federal policy lay unchallenged," she continues. She writes that she "suspect[s] that anti-choicers latched onto taxpayer-funded abortions because they can count on a lot of the public to imagine the government funding female licentiousness." Marcotte concludes that the "good news is that this contempt for female sexuality has receded enough that the media debate hasn"t -- yet -- turned to whether or not health care reform should cover contraception" (Marcotte, RH Reality Check, 7/28).~ "Privileging Opposition to Abortion," Jamison Foser, Media Matters for America: Some reporters "have skewed their reports in favor of those who oppose" coverage of abortion in federally subsidized insurance plans, according to Foser. For example, Foser writes that on a recent episode of MSNBC"s "Hardball," host Chris Matthews asked Sens. Richard Durbin (D-Ill.) and Orrin Hatch (R-Utah) "leading questions that encouraged them to state their opposition to insurance coverage of abortion" but never asked them "one simple question: Why shouldn"t abortion be covered, given that the procedure is legal?" Foser adds, "Nor has he asked if there are any other legal procedures that shouldn"t be covered." The "premise that taxpayers who oppose abortion shouldn"t have to pay for them with their tax money carries obvious implications the media ignores," Foser writes. He adds that the "idea that taxpayers shouldn"t pay for insurance that covers medical services they don"t support is fundamentally incompatible with the very concept of insurance." He continues, "If every interest group wields veto power over the medical care insurance can cover, insurance simply can"t work." However, this is not the "only logical inconsistency on the part of abortion foes that the media fail to examine" in their coverage of abortion issues in the health reform debate, he writes. "Many of those who are most adamant that the government not allow abortion to be paid for by health insurance plans are the same conservatives who argue against health care reform by warning of the prospect of a government bureaucrat getting between you and your doctor," according to Foser. He continues that the "same people who want a government ban on insurance coverage for a legal medical procedure turn around and demagogue about government bureaucrats making medical decisions," which is "a pretty obvious inconsistency, the kind any reporter should be able to spot easily." However, the "tension between those two positions has gone unexplored in news reports about the abortion controversy," Foser concludes (Foser, Media Matters for America, 7/24).~ "Obama Abortion Backtrack Shows He"s All Rhetoric, No Fight," Bonnie Erbe, U.S. News & World Report"s "Thomas Jefferson Street": "[O]ne thing we know will not be incl
As they worked to move health care reform legislation through the Energy and Commerce Committee, House Democrats said they were close to a compromise with fiscally conservative Democrats, a group that so far has been a roadblock, The Hill reports.
The Washington Post tells the story of Danny Watt, who drowned in April 2008 after a lifelong struggle with mental health. Watt had a dual diagnosis: a serious mental illness along with abuse of drugs or alcohol.
Children who were exposed to Plasmodium falciparum "malaria before birth become tolerant to the malaria parasite, or their soluble products," according to a PLoS Medicine study, which has "unravelled the mystery behind why some children are more susceptible to malaria infection and anaemia," ANI/Newstrack India reports. This tolerance, which persists after birth and into childhood, erodes the immune system"s ability to attack and destroy parasites and increases the susceptibility of these children to develop a malaria infection and increases their risk for anemia (7/28).
In an open letter to Cambodia"s prime minister and health minister, more than 100 international HIV/AIDS advocates and human rights organizations "accused the Cambodian government of herding HIV-affected families into an "AIDS colony" outside the capital, Phnom Penh," the Guardian reports (McCurry, 7/28).
Walter and Eliza Hall Institute scientists have created a weakened strain of the malaria parasite that will be used as a live vaccine against the disease. The vaccine, developed in collaboration with researchers from the US, Japan and Canada, will be trialled in humans from early next year.
A new urine test developed with funding from the Wellcome Trust will allow doctors to diagnose Chlamydia infection in men within the hour, improving the ability to successfully treat the infection on the spot and prevent re-transmission.
New research supports the findings of a landmark drug comparison study published in 2002 in which a diuretic drug or "water pill" outperformed other medications for high blood pressure. A scientific team including investigators from The University of Texas Health Science Center at Houston reports the findings in the May 11 issue of the Archives of Internal Medicine.
E-mail, search engines, smart phones and other new technologies that can disseminate new medical information quickly led to an almost immediate change in clinical practice for drug-eluting stents, according to a study reported in Circulation: Cardiovascular Quality and Outcomes.
Georgia has received $63.9 million in Ryan White Program grants to fund treatment and other services for people living with HIV, the Atlanta Journal-Constitution reports. Grant recipients include county health departments and community organizations. The funding will be used to provide outpatient health services, health insurance coverage and support services, such as transportation and housing. According to the Journal-Constitution, more than $1.79 billion in Ryan White funding was allocated nationwide. Several HIV/AIDS organizations said that the funding is necessary to continue providing services for people living with the disease. Tracy Elliot, executive director of AID Atlanta, said that the funding is "critical," noting that more than 18,000 HIV/AIDS cases have been reported in Georgia. He continued, "We would have a lot of deaths without [the funding]. There would be significantly more illnesses without it and significantly more transmission of the disease without it." According to Elliot, "[m]edical treatment and medications are of no value if people cannot have access to them" (Poole, Atlanta Journal-Constitution, 5/19).
The assumption that gangs are at the root of gun crime in the UK is overstated, according to a study published in a special issue of Criminology and Criminal Justice, published by SAGE.
Researchers at The University of Queensland have helped identify genes that could hold the key to treating a common and deadly type of breast cancer.
The US-based PATH Malaria Vaccine Initiative (MVI), the United States Agency for International Development (USAID) Malaria Vaccine Development Program (MVDP), and Dutch biopharmaceutical company Crucell N.V. today announced a collaboration to accelerate development of a promising type of malaria vaccine. Through funding from the USAID MVDP, the partners will conduct studies to determine the effectiveness of Crucell"s novel prime-boost vaccine approach against the malaria parasite, Plasmodium falciparum. This approach uses Crucell"s proprietary recombinant adenoviruses (a type of virus associated with the common cold and other mild respiratory infections) to deliver a malaria antigen to the immune system.
Biotech firm Replikins Ltd. released its analysis of the June and July genomic data that predicts the rates of infectivity and lethality of the H1N1 (Swine Flu) virus. The quantitative analysis shows continued elevated levels in the Replikin Counts* of both Infectivity and Lethality genes, which indicate that the end of the current outbreak is not yet in sight.
The growth of acute stroke care centres and systems of care could revolutionise clinicians" ability to treat patients with stroke, according to an analysis of services published ahead of print in the Journal of NeuroInterventional Surgery.
Trusted health care s and continuity of care may help reduce the risk of prostate cancer deaths in African-American men, according to a study published in the current issue of the journal Cancer. James Mohler, MD, Chair of the Department of Urology at Roswell Park Cancer Institute (RPCI), and William R. Carpenter, PhD, Department of Health Policy and Management at the University of North Carolina, are lead investigators.
Scott Roeder, the man charged with the May 31 shooting death of abortion provider George Tiller, pleaded not guilty to first-degree murder and aggravated assault at a Wichita, Kan., hearing on Tuesday, the AP/Boston Globe reports (AP/Boston Globe, 7/29). After witnesses described events surrounding the shooting, the judge presiding over the hearing concluded that there was sufficient evidence to try Roeder. Tiller was murdered in the foyer of his church, where he was serving as an usher. According to several church members who testified Tuesday, Roeder occasionally had come to the church in the months before the shooting.The trial is scheduled to begin Sept. 21 (Davey, New York Times, 7/28). At the hearing, Roeder made no public comments, and the not-guilty plea was entered by the public defender representing him in the case (AP/Boston Globe, 7/29).If convicted, Roeder likely will face life in prison, as the case does not meet state criteria for the death penalty. His lawyers declined to comment on their defense plans (New York Times, 7/28).
"Senate Democrats debating how to overhaul America"s healthcare system are moving toward a showdown over whether to create a government-run insurance program or set up a system of cooperatives instead," the Los Angeles Times reports. The public plan, endorsed by Obama, is an important goal for many liberals, but Republicans strongly oppose expanding Washington"s role in health care. The Senate centrists who are now driving the debate from the Finance Committee, are "leaning towards" the cooperatives which would be owned by their members, rather than controlled by the government. The hope is the compromise will attract a degree of bipartisan support (Levey and Hook, 7/29).
Massachusetts lawmakers will vote today to provide $40 million to restore health care coverage for legal immigrants.
The Pittsburgh Post-Gazette profiled the Girlfriends Project, a domestic violence and HIV/AIDS education program implemented by the Pittsburgh AIDS Task Force that targets at-risk black women in three Allegheny County, Pa., cities. Blacks "comprise just 7 percent of the total population in southwestern Pennsylvania but 41 percent of those living with HIV/AIDS, according to Allegheny County Health Department statistics provided by the task force," the Post-Gazette reports. "The Girlfriends Project was designed for Braddock, Clairton and Duquesne "because we knew nobody was doing outreach there," project coordinator, Lisa Dukes, said. As part of the project, Dukes hosts Tupperware party-style gatherings in homes of residents where she provides HIV testing and education, sexual health information, safe sex products and cash gift cards. The project is an outgrowth of the CDC"s prevention program Sisters Informing Sisters About Topics on AIDS, or SISTA, and has been so successful that CDC "has asked the task force to introduce it at the CDC"s 2009 National HIV Prevention Conference in Atlanta Aug. 23," the article states (Smith, 7/29).
Today there are an estimated 5.3 million Americans with Alzheimer"s disease. Although the majority of Alzheimer cases are individuals age 65 and older, there is still a significant number of individuals under age 65 impacted by this fatal disease that today has no cure. For people under age 65 with Alzheimer"s disease or a related dementia, their cognitive impairment can quickly reach a point where they can no longer maintain gainful employment. The Alzheimer"s Association applauds the Social Security Administration (SSA) for holding a hearing today to examine whether these individuals with younger-onset Alzheimer"s disease or related dementias should be included in its Compassionate Allowances Initiative.
Adults who use less salt in their diet can experience a slight reduction in their blood pressure in the medium term. However, whether in the long term this can also reduce the risk of late complications in people with sustained high blood pressure, otherwise known as essential hypertension, and whether in the long term their anti-hypertensive medication can be reduced remains unresolved. This is the conclusion of the Institute for Quality and Efficiency in Health Care (IQWiG) in its final report published in the form of a rapid report on 20 July 2009.
Scientists in the US have found a way of slowing the growth of ovarian cancer tumors in mice by using nanoparticles to deliver suicide genes to
If you"ve ever felt doomed to repeat your mistakes, researchers at MIT"s Picower Institute for Learning and Memory may have explained why: Brain cells may only learn from experience when we do something right and not when we fail.
In what will be the Stem Cell Awareness Association"s seventh awareness rally, past patients, interested physicians, and prospective patients will meet in Manchester to learn about stem cell technologies and discuss the various current treatments available throughout the world.
By systematically analysing MRI changes occuring in the brains of children with the metabolic disease glutaric aciduria type I researchers at Heidelberg University Hospital have succeeded for the first time in demonstrating reversible and permanent brain damage as well as elucidating its temporal evolution.
The ability to mount an immune response to influenza A (H1N1) infection is significantly compromised by a low level of arsenic exposure that commonly occurs through drinking contaminated well water, scientists at the Marine Biological Laboratory (MBL) and Dartmouth Medical School have found.
Osteoarthritis (OA), the most common joint disorder throughout the world and a leading cause of disability, is characterized by pain, impaired joint mobility, reduction of muscular strength and loss of joint function. Unlike most other common diseases, little is known about its origins, and factors predicting a severe disease course have not been identified. A new study, the first to establish a laboratory marker for the risk of severe OA, found that vascular cell adhesion molecule 1 (VCAM-1), was a strong predictor of hip and knee joint replacement due to severe OA. The study was published in the August issue of Arthritis & Rheumatism .
Inovio Biomedical Corporation (NYSE Amex: INO), a leader in DNA vaccine design, development and delivery, announced that the company"s SynCon™ H1N1 influenza DNA vaccines achieved protection against current circulating swine origin influenza A/H1N1 viruses in animal studies.
Smokefree Innotec, Inc. (Pink Sheets: SFIO) issued a statement referring to articles in USA Today and The New York Times of Wednesday, July 22, and Thursday, July 23rd, regarding the FDA taking aim at electronic cigarettes. The national dailies stated that tests show that certain e-cigarettes contain "known carcinogens and toxic chemicals," including diethylene-glycol (an ingredient used in antifreeze, printing ink, brake fluid and glue) and nitrosamine (which is used in rubber products, the tobacco industry, and - less concentrated - in beer and fish-products).
U.S. Senators Mel Martinez (R-FL) and Evan Bayh (D-IN) introduced a measure to create a collaborated system for researching, treating and eliminating Alzheimer"s disease. The proposal will create an Office of the National Alzheimer"s Project within the White House, and will coordinate all research, clinical care and service toward the prevention, care, and cure of Alzheimer"s. This office will produce a national strategic plan to help assure that the millions of Americans who now have Alzheimer"s and the millions of potentially at-risk Americans will have a coordinated effort to target the 6th leading cause of death in the United States.
Responding to the publication of the Public Accounts Committee report, Reducing Alcohol Harm: health services in England for alcohol misuse, Dr Peter Carter, Chief Executive of the Royal College of Nursing (RCN), renews the call for tighter alcohol regulation. He said:
A new analysis finds that women in New Jersey who take the breast cancer drug tamoxifen in conjunction with certain popular antidepressants may be at a higher risk for a breast cancer recurrence.
WellPoint, Inc. (NYSE: WLP) announced today that it will offer coverage for the administration of the H1N1 (swine flu) vaccine when it becomes commercially available to the general public. The vaccine administration will be covered for members whose benefit plans provide coverage for vaccines.
An estimated 428,000 residents in New Mexico could lose their private, employer-based coverage if Congress passes a House health reform bill, according to state-specific analysis of The American Affordable Health Choices Act of 2009 released this week by The Heritage Foundation.
In the days leading up to Glen Deaton"s emergency trip from Trumann to the University of Arkansas for Medical Sciences (UAMS), large veins that drain blood from his brain were clotting.
Doctors" leaders are warning that unless urgent action is taken to plug the gap in the shortage of middle grade doctors, the NHS in Wales could become unsafe both for staff and patients.
When the H1N1 flu vaccine becomes available in the fall, pregnant women should be among the first groups vaccinated because of their high risk for serious complications, a Centers for Disease Control and Prevention expert panel said on Wednesday, the Washington Post reports. The 15-member committee advises CDC on vaccine policy. The priority list also includes caretakers of infants, health care workers, children and young adults, and older people with chronic conditions. Anthony Fiore, a physician and epidemiologist at CDC, told the committee that about 6% of H1N1 deaths and hospitalizations are among pregnant women (Brown, Washington Post, 7/30). According to a CDC study published online Wednesday in the journal Lancet, pregnant women who contract the H1N1 virus -- also known as "swine flu" -- are at least four times more likely to be hospitalized than other people with the virus, the AP/Google reports. The study analyzed the first 34 U.S. cases, including six deaths, in pregnant women from April to mid-June of 2009. Although it is not clear if pregnant women are more susceptible to the virus, they have a higher risk of complications after becoming infected. The study"s authors said pregnant women suspected of having H1N1 should be administered Tamiflu as soon as possible, prior to the completion of diagnostic testing. CDC"s Denise Jamieson, the lead author of the study, said that Tamiflu appears relatively safe for pregnant women, despite limited safety data on its use in that population.Most pregnant women who contract H1N1 have mild flu symptoms like a cough or fever, according to the World Health Organization. Jamieson said that CDC does not recommend specific precautions for pregnant women but that doctors should act quickly -- preferably within 48 hours -- if a pregnant woman shows symptoms. She added that the pregnant women who died were basically healthy, and nearly all had viral pneumonia before experiencing acute respiratory problems prior to their death (Cheng, AP/Google, 7/29).CDC"s priority groups include about 159 million people out of a total U.S. population of more than 300 million, the Chicago Tribune reports. The agency expects to have about 120 million doses of the vaccine by the end of October. Officials are confident there will be enough for their target groups because only 20% to 50% of those recommended to receive seasonal flu vaccines seek them out. However, if supplies of the vaccine are unexpectedly restricted, the panel recommended that a smaller group -- about 41 million of the most susceptible to adverse side effects from infection or most likely to spread the virus -- be given priority for the vaccine. This smaller group also includes pregnant women (Maugh, Chicago Tribune, 7/30).
Hepatitis C virus (HCV) is a blood-borne disease that causes inflammation of the liver and to which there is currently no vaccine available. The World Health Organization (WHO) estimates that 3% of the world"s population, approximately 170 million people, are infected with HCV and it is a leading cause of liver cirrhosis, end stage liver disease, hepatocellular carcinoma (HCC) and liver transplantation.
The following summarizes recent research related to ovarian cancer.~ Early periods linked to lower survival: Women who start menstruating at an early age or experience more menstrual cycles over their lifetimes appear to have a lower chance of surviving ovarian cancer, according to a study published this month in the journal Cancer Epidemiology, Biomarkers, and Prevention, Reuters reports. For the study, researcher Cheryl Robbins and colleagues analyzed the medical data of 410 ovarian cancer patients who participated in the Cancer and Steroid Hormone study between 1980 and 1982. The analysis found that the women who had their first period before age 12 had a 51% greater risk of dying than the women who began menstruating at age 14 or older. The women who had the highest number of lifetime menstrual cycles had a 67% greater risk of dying during follow-up than the women with the lowest number of cycles (Reuters, 7/24).~ Lung cancer risk higher for women after hysterectomy with ovary removal: Women who have had hysterectomies in which their uterus and both ovaries are removed to prevent ovarian cancer appear to have a higher risk for developing lung cancer, according to researchers at the University of Montreal, the New York Times reports. The researchers discovered the connection while looking for links between lung cancer and hormones for a study published in May in the International Journal of Cancer. Although they did not find a relationship between lung cancer risk and hormonal factors such as menstruation patterns, child-bearing or breastfeeding, the researchers found that women who had medically induced menopause had 1.92 times greater risk of developing lung cancer than women who had natural menopause (Caryn Rabin, New York Times, 7/24).~ Small tumors present for years before detection: Minute-sized ovarian tumors form and remain in the Fallopian tubes for an average of four years before they grow large enough to be detected, which might suggest why ovarian cancer frequently is diagnosed in its later stages, according to a study published in the journal PLoS Medicine, Reuters reports. For the study, lead researcher Patrick Brown of Stanford University and the Howard Hughes Medical Institute and colleagues analyzed the tumors of women whose Fallopian tubes and ovaries were removed because they had family histories of and genetic risk for ovarian cancer. They found small tumors -- most less than three millimeters in diameter -- that previously had not been detected in the women. In a statement, Brown said, "There is a long window of opportunity for potentially lifesaving early detection of this disease, but the tumor spreads while it is still much too small to be detected by any of the tests that have been developed or proposed to date." According to Reuters, blood tests for the compound called CA-125 may help guide therapy but do not indicate whether a woman has a tumor (Reuters, 7/28).
New wiki supports collaboration and accelerates progress on using clinical decision support for healthcare performance improvement
This is the time of year when even teens who have never tried a drop of alcohol may be tempted. Middle and high school proms and graduation are big events and there will be multiple parties to attend and a wide array of opportunities for alcohol to be served.
Under economic pressure, states are slashing funding for health services from Connecticut to California. The cuts frustrate providers and lawmakers are looking for ways to limit harm.
Congress Needs To Think Big About Medicare Fix Politico
During a meeting in Atlanta on Wednesday, a "federal advisory committee issued sweeping guidelines ò€¦ for a vaccination campaign against the pandemic swine flu strain, identifying more than half the U.S. population as targets for the first round of vaccinations," CNN reports (Hellerman, 7/29).
University of Minnesota Project Eating Among Teens (EAT) researchers have identified factors that may increase overweight adolescents" risk of engaging in extreme weight control behaviors such as self-induced vomiting, the use of diet pills, laxatives, and diuretics, as well as binge eating. Overweight youth with certain socio-environmental, psychological, and behavioral tendencies, such as reading magazine articles about dieting, reporting a lack of family connectedness, placing a high importance on weight, and reporting having participated in unhealthy weight control behaviors, are more likely to suffer from eating disorders.
Health plans reiterated their strong support for new market rules and consumer protections to cover all Americans and guarantee coverage for pre-existing conditions.
The incidence of a rare and deadly tumor called primary central nervous system lymphoma (PCNSL) is two times higher in black Americans, ages 20 to 49, than in white Americans, according to a Mayo Clinic study published in the June issue of Journal of Neuro-Oncology. In patients older than 49, the results were reversed. White Americans were twice as likely as black Americans to be diagnosed with PCNSL.
In this week"s New England Journal of Medicine, scientists in Singapore, The Netherlands and France report that they have developed a novel immunization method that will induce fast and effective protection in humans against the life-threatening malaria parasite, Plasmodium falciparum, which infects 350 to 500 million people world-wide and kills over one million people each year.
One of the most well-known psychological tools is the Rorschach Inkblot Test. A viewer looks at ten inkblots, one at a time, and describes what they see. The rationale behind this test is the idea that certain aspects of the subject"s personality will be exposed as they are interpreting the images, allowing for the possible diagnosis of various psychological disorders. However, does the inkblot really reveal all? Psychological Science in the Public Interest, a journal of the Association for Psychological Science, published an exhaustive review of all data on the Rorschach (and other similar "projective" tests) in 2000. Such meta-analyses are major undertakings, so although this report is a few years old, it remains the most definitive word on the Rorschach. According to authors Scott O. Lilienfeld of Emory University, James M. Wood of University of Texas at El Paso, and Howard N. Garb of the University of Pittsburgh, despite its popularity, the Rorschach may not be the best diagnostic tool and practitioners need to be cautious in how they use this technique and interpret their results.
Hopkins experts in applied physics, computer engineering, infectious diseases, emergency medicine, microbiology, pathology and surgery have unveiled a 7-foot-tall, $10,000 shower-cubicle-shaped device that automatically sanitizes in 30 minutes all sorts of hard-to-clean equipment in the highly trafficked hospital emergency department. The novel device can sanitize and disinfect equipment of all shapes and sizes, from intravenous line poles and blood pressure cuffs, to pulse oximeter wires and electrocardiogram (EKG) wires, to computer keyboards and cellphones.
The American Medical Student Association (AMSA), the nation"s oldest and largest, independent association for physicians-in-training, is pleased to present the graduates of the AMSA Foundation-VITAS End of Life Education Fellowship Program. Five medical students have spent the past six weeks immersing themselves in end of life (EOL) care issues.
This month"s Ophthalmology, the journal of the American Academy of Ophthalmology, reports on the use of bevacizumab (Avastin) to benefit diabetic patients with macular edema as well as people who develop cystoid macular edema after cataract surgery. Bevacizumab is also used to treat some cancers. A third study describes methods that could make cataract surgery safer for diabetic retinopathy (DR) patients. DR is the major threat to vision in working-age people, a health issue that will only intensify if cases triple by 2050 as predicted.
In response to the publication of the report, Lynda Hamlyn, Chief Executive of NHS Blood and Transplant, said:
Johns Hopkins experts in applied physics, computer engineering, infectious diseases, emergency medicine, microbiology, pathology and surgery have unveiled a 7-foot-tall, $10,000 shower-cubicle-shaped device that automatically sanitizes in 30 minutes all sorts of hard-to-clean equipment in the highly trafficked hospital emergency department. The novel device can sanitize and disinfect equipment of all shapes and sizes, from intravenous line poles and blood pressure cuffs, to pulse oximeter wires and electrocardiogram (EKG) wires, to computer keyboards and cellphones.
Allergan, Inc. (NYSE: AGN) announced that the United States Food and Drug Administration (FDA) has approved ACUVAIL(TM) (ketorolac tromethamine ophthalmic solution) 0.45%, an advanced, preservative-free formulation of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) indicated for the treatment of pain and inflammation following cataract surgery. Cataracts are a leading cause of blindness among older adults and cataract surgery is the most frequently performed surgical procedure in the United States, with more than 3 million procedures performed each year.1
GlaxoSmithKline (GSK) and Genmab A/S (OMX: GEN) announced preliminary top-line results from a Phase III study of ofatumumab administered intravenously for the treatment of rheumatoid arthritis (RA) in patients who had an inadequate response to methotrexate. The study met the primary endpoint, ACR20 at 24 weeks, which indicates a 20 percent or greater improvement in the number of swollen and tender joints, as well as improvements in other disease-activity measures.
GSK announced that it has notified the European Medicines Agency of its decision to withdraw the Marketing Authorisation Application (MAA) in the EU for mepolizumab for the treatment of hypereosinophilic syndrome (HES).
The biotechnology medicine Ilaris® (canakinumab) has passed another major milestone with a recommendation for approval in the European Union to treat patients with a life-long and potentially fatal auto-inflammatory disease called cryopyrin-associated periodic syndrome (CAPS). When approved, Ilaris will be the only treatment in the EU indicated for CAPS patients aged four years and older[1].
Parkinson"s disease is well-known for impairing movement and causing tremors, but many patients also develop other serious problems, including sleep disturbances and significant losses in cognitive function known as dementia.
Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates can also induce a strong immune response, causing toxic side effects. Understanding how siRNA stimulates this undesirable immune activity, how to test for it, and how to design siRNA drugs to avoid it are critical topics explored in a timely review article published online ahead of print in Oligonucleotides, a peer-reviewed journal published by Mary Ann Liebert, Inc.
Patients with second primary lung cancers (SPLC), when compared to those with one primary lung cancer (OPLC), are more likely to have localized disease at the time of diagnosis and are more likely to receive surgical treatment rather than radiation treatment. However, patients with SPLC have a 12% higher lung cancer specific mortality, Fox Chase Cancer Center researchers reported at the annual meeting of the International Association for the Study of Lung Cancer.
Some people who are serious about wanting to reduce their "carbon footprint" on the Earth have one choice available to them that may yield a large long-term benefit - have one less child.
Low blood pressure is also known as hypotension. For millions of people who suffer from hypertension (high blood pressure) hypotension may seem great. If symptoms are mild hypotension usually requires no treatment. However, it can cause serious heart disorders, fainting and also lead to neurological and endocrine disorders. If hypotension is severe key organs can become deprived of oxygen and nutrients and the body can go into shock, a life-threatening condition.
The ghrelin hormone not only stimulates the brain giving rise to an increase in appetite, but also favours the accumulation of lipids in visceral fatty tissue, located in the abdominal zone and considered to be the most harmful. This is the conclusion of research undertaken at Metabolic Research Laboratory of the University Hospital of Navarra, published recently in the International Journal of Obesity.
HHS Secretary Kathleen Sebelius and Agriculture Secretary Tom Vilsack announced today that prevention and partnership will guide their departments" efforts to safeguard the food Americans eat every day. Both Secretaries announced new strategies that focus on prevention and depend on working closely with growers, food processors and consumers to achieve their goals.
Data presented today at the 8th European Congress on Menopause
By combining the art of origami with nanotechnology, Dana-Farber Cancer Institute researchers have folded sheets of DNA into multilayered objects with dimensions thousands of times smaller than the thickness of a human hair. These tiny structures could be forerunners of custom-made biomedical nanodevices such as "smart" delivery vehicles that would sneak drugs into patients" cells, where they would dump their cargo on a specific molecular target.
Four simple questions on well-being asked at the start of each session of ongoing couples therapy can greatly increase chances for reconciliation and improved relationships, according to a newly published study. The largest clinical trial with couples to date, it shows that divorce and separation rates for couples that used this feedback technique were 46.2 percent less than that of couples who received therapy as usual. The findings, published in the August 3, 2009, Journal of Consulting and Clinical Psychology, are the results of a 2-year study conducted at the Vestfold Family Counseling Center in Norway by a U.S.-Norwegian team of researchers.
As people age, the potential exists for those years to be the most rewarding and fulfilling time of their lives. However, major illness, retirement, the death of a spouse, and a shrinking circle of friends all may, in some cases, contribute to increased levels of stress and depression in the elderly. For that reason the chief of geropsychiatry for the Los Angeles Jewish Home - the largest single- provider of senior residential housing in the western United States - is offering seniors and their loved ones 10 warning signs that may trigger the need for assistance with mental health issues.
InfoLogix, Inc. (Nasdaq: IFLG), a leading technology provider of enterprise mobility solutions for the healthcare and commercial industries, announced the introduction of a new mobility offering for healthcare providers, the InfoLogix M24 mobile clinical assistant: a powerful mobile computing solution that enables medical professionals to access critical patient information at the point-of-care.
Smoking bans, while a necessary and positive trend for reducing exposure to secondhand smoke, have some unintended consequences--especially for women. The August 2009 issue of the American Journal of Preventive Medicine includes a special supplement, Unintended Consequences of Tobacco Policies, a compilation of nine original, peer-reviewed articles focused on examining these unique challenges related to a smoking stigma, childcare and personal safety.
A paper just published in the British Journal of Pharmacology reports that a compound originally isolated from a soft coral (Capnella imbricate) could lead scientists to develop a new variety of treatments for neuropathic pain. This composite is collected at Green Island off Taiwan and could be a new option for treatment. Neuropathic pain is chronic and occasionally follows damage to the nervous system. Presently this type of pain is very poorly controlled by the usual analgesics: aspirin like drugs (NSAIDS) or even opioids like morphine. New treatments are urgently required.
Democrats are finding points they agree on in a tenuous accord for the message they want to relay to constituents during the August recess: The health insurance industry is the bad guy, The Washington Post reports.
In an interview with the Seattle Post-Intelligencer, Washington state Insurance Commissioner Mike Kreidler called the American health system an out-dated, World War II-era obstacle to economic progress. "We"ve been talking about health-care reform in this country for over 100 years, and its never happened," he said. However, he added, "I believe that Congress will be successful." Kreidler, a Democrat, was a member of Congress in the 1990s, when the Clinton administration attempted an overhaul. This time around, he said, "We"re still in July, and they"re making huge progress" (Pulkkinen, 8/2).
A recently passed House spending bill that lifts the ban on the use of federal funding for needle exchange programs, which included an amendment addressing the locations of needle exchanges, "according to many health and human rights advocates, has been diluted to the point that it won"t help the same urban areas most afflicted by" blood-borne illnesses such as HIV, the Washington Independent reports. House Appropriations Committee Chair David Obey (D-Wis.) added an amendment to the bill that prohibits needle exchanges from operating "within 1,000 feet of schools, daycare centers and other areas where children are likely to congregate," according to the Independent. Obey "included the restriction, not because he supports it, but to appease conservative critics who might have killed the entire provision otherwise," the article states. William McColl, political director for AIDS Action, said, "In an urban environment, that really is a restriction on almost anywhere."
California HIV/AIDS service providers recently met to analyze how Gov. Arnold Schwarzenegger"s (R) recent funding cuts to the state Office of AIDS "would affect county health programs, non-profit service providers and their clients," the California Progress Report reports. Anne Donnelly, director of health care policy for Project Inform, said that organizations that rely mostly on private donations and federal grants will likely be less affected by the cuts than medical clinics, early intervention and prevention outreach groups. She added, "It"s probably going to be the minority-based, smaller organizations that work in under-served communities and have been totally dependent on those [state] funds," that will be hardest hit. "According to [Phil Curtis, director of government affairs with AIDS Project Los Angeles], the full impact of the governor"s cuts to the clients of his and other organizations will be known only after Los Angeles and other cash-strapped counties determine how to distribute the cuts next week," the article states (Aiello, 7/31).
The Washington Post examines the devastating toll the conflict in the Congo has had on the health of the country"s displaced civilians, as told through the death of a 36-year-old farmer, who succumbed to typhoid fever far away from the home he abandoned. The newspaper writes, "By some estimates, at least 5 million Congolese have died in more than a decade of conflict touched off by the 1994 genocide in neighboring Rwanda, which sent a flood of militiamen across the border into mineral-rich eastern Congo."
Rummaging through a biotechnology company"s chemical closet, Yale University researchers found two molecules that will allow scientists to better study how cells move. The study in the journal Nature, published online Aug. 2, describes how two small molecules discovered by Cytokinetics Inc. block the action of a key complex that directs the assembly of actin filaments, which produce the force to help cells move. The target of these inhibitors is the Arp2/3 complex, a cellular component so vital that cells die without it. This dependence has made it challenging to learn exactly which cellular processes depend upon the complex.
Our cells are controlled by billions of molecular "switches" and chemists at UC Santa Barbara have developed a theory that explains how these molecules work. Their findings may significantly help efforts to build biologically based sensors for the detection of chemicals ranging from drugs to explosives to disease markers.
About half of the car trips in the U.S. are less than five miles - a distance easily navigated by walking or cycling. Reducing short-distance car trips has many benefits - it decreases car accidents, has positive benefits for the environment and increases physical health and activity, says communication professor Edward Maibach of George Mason University. An expert in climate change communication research, Maibach says that community leaders should make promotion of physical activity a priority.
Like the sensitive seismographs that can pick up tremors of impending earthquakes long before they strike, a similar invention from Tel Aviv University researchers may change the face of molecular biology.
Responding to the Innovation, Universities, Science and Skills Committee (IUSS) report on "Students and Universities" Professor Paul Wellings, Chair of the 1994 Group of leading research intensive universities and Vice-Chancellor of Lancaster University said:
Interventional radiology procedures are on the rise in developing countries and there is a significant need for optimization of these procedures to ensure patient safety. Many facilities in these countries lack the concept of patient dose estimation and dose management, putting patients at a higher risk of developing complications due to overexposure from radiation during interventional procedures, according to a study performed by the International Atomic Energy Agency in Vienna, Austria.
La Jolla Institute for Allergy and Immunology researchers studying an enzyme believed to play a role in allergy onset, instead have discovered its previously unknown role as a tumor suppressor that may be important in myeloproliferative diseases and some types of lymphoma and leukemia. Myeloproliferative diseases are a group of disorders characterized by an overproduction of blood cells by the bone marrow and include chronic myeloid leukemia. Lymphoma and leukemia are cancers of the blood.
The new anti-wrinkle facial filler Dysport, which could be used as an alternative to Botox, noticeably reduced frown lines between the eyes, according to users and independent reviewers in a study involving plastic surgeons at UT Southwestern Medical Center.
The world"s top lung cancer specialists, medical professionals and researchers are convening this week in San Francisco, CA for the 13th World Conference on Lung Cancer (WCLC), organized by the International Association for the Study of Lung Cancer (IASLC). As non-small cell lung cancer (NSCLC) is one of the most common types of lung cancer affecting a heterogeneous population, researchers have focused on multi-modality treatment regimens to improve patient outcomes. According to research showcased today at the WCLC, multi-modality, tailored treatment regimens increased patient survival rates compared to single-agent therapies.
Drug companies may exploit new rules to promote their products to the public but present it as mere provision of information, according to an editorial published this week in the Drug and Therapeutics Bulletin (DTB).
Boehringer Ingelheim announced today at the International Association for the Study of Lung Cancer"s 13th World Conference on Lung Cancer (WCLC), San Francisco, CA, the initiation of a Phase III clinical study of BIBW 2992 as first-line treatment in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations. BIBW 2992 (planned brand name Tovok™) is the first orally-administered, irreversible dual inhibitor of EGFR and HER2,1 to reach Phase III development in NSCLC.2
Sirtuin proteins have been shown to promote longevity in many organisms, and increased expression of one sirtuin protein, SIRT3, has been linked to increased human lifespan. New data, generated in mice, by Mahesh Gupta and colleagues, at the University of Chicago, Chicago, has revealed that Sirt3 helps protect the mouse heart.
Small-scale farmers in Africa, Asia and Latin America are
Congressman Michael C. Burgess, M.D. (R-Texas) sent a letter to President Obama yesterday accepting his invitation to "come over to the White House and go over line-by-line" the health care reform plan the President is pushing.
Researchers at the University of Pittsburgh School of Medicine have learned that some healthy people naturally developed an immune response against a protein that is made in excess levels in many cancers, including breast, lung, and head and neck cancers. The finding suggests that a vaccine against the protein might prevent malignancies in high-risk individuals.
Eiger BioPharmaceuticals, Inc., a biotechnology company developing antiviral therapies, announced today that it has licensed the exclusive worldwide rights to novel Hepatitis C Virus (HCV) technology from Stanford University. This technology, discovered in the lab of Stanford scientist and Eiger founder Dr. Jeffrey Glenn, M.D., Ph.D., is focused on a variety of novel targets, including key features of NS4B, a non-structural protein in the HCV genome, which binds to HCV-RNA and is required for viral replication.
WHAT: The Nutrient-Rich Foods (NRF) Index is a new, objective, science-based way to measure the total nutritional quality of foods and beverages.
The full Senate on Tuesday is set to begin debate on Supreme Court nominee Sonia Sotomayor, who is widely expected to be confirmed by the end of the week, the Los Angeles Times reports (Savage/Oliphant, Los Angeles Times, 8/4).Six Republicans have announced that they will vote to confirm Sotomayor, while most are aligning with the party base to vote against her confirmation. No Democrats have announced that they will oppose her nomination. At the risk of alienating his state"s large Hispanic population, Sen. John McCain (R-Ariz.) on Monday announced that he will oppose Sotomayor"s confirmation (AP/USA Today, 8/4). "An excellent resume and an inspiring life story are not enough to quality oneself for a lifetime of service on the Supreme Court," McCain said, adding, "I do not believe she shares my belief in judicial restraint" (Los Angeles Times, 8/4). Sen. Ben Nelson (D-Neb.), an advocate for gun-rights, had been under pressure to vote against her but on Monday said that he supports the nominee and will vote to confirm her. Nelson said that he believes Sotomayor has "a great respect for the law" (AP/USA Today, 8/4).
The following summarizes select women"s health-related blog entries.~ "ACLU Files Brief Opposing Forced Hospitalization of Pregnant Women," Jodi Jacobson, RH Reality Check: On Monday, the American Civil Liberties Union and the ACLU of Florida "filed a friend-of-the-court brief opposing the state"s decision to force a pregnant woman to remain hospitalized against her will," Jacobson writes. According to Jacobson, Diana Kasdan, a staff attorney with ACLU"s Reproductive Freedom Project, said, "Women do not give up their right to determine the course of their own medical care when they become pregnant. Faced with similar cases, courts throughout the country have made clear that pregnant women have a right to make decisions about their own health, including refusing medical care." The brief filed by ACLU also said that Florida"s decision will "invit[e] state requests for court intervention in nearly all aspects of pregnant women"s behavior and medical judgments." Women "will be discouraged from coming to a hospital for pregnancy care if they know that any disagreement may lead to forced medical treatment," the brief continues, noting that "[s]uch a result does not advance maternal and fetal health by any measure and is not constitutionally permissible" (Jacobson, RH Reality Check, 8/3).~ "Rubber-Baby Money Lumpers," William Saletan, Slate"s "Human Nature": National Right to Life Committee Legislative Director Douglas Johnson has "restated ... many times" that the group has a neutral position on contraception, Saletan writes, adding that he is "inclined to believe him, because I take people"s stated motivations seriously." However, Johnson "doesn"t take such motivations seriously" and "relentlessly characterizes his opponents as "pro-abortion," even though they don"t like abortion" and refer to themselves as "pro-choice" or "pro-abortion rights," Saletan continues. Johnson"s "latest targets" are Reps. Tim Ryan (D-Ohio) and Rosa DeLauro (D-Conn.), who sponsored the Preventing Unintended Pregnancies, Reducing the Need for Abortion and Supporting Parents Act. The measure includes funding for contraception and sex education, as well as incentives and support for adoption and women who carry their pregnancies to term. However, Johnson "dismisses the Ryan-DeLauro bill and its themes of abortion reduction and common ground as "phony," a "smokescreen," and a "prop" in a "political charade,"" he continues. Johnson "insists on an objective standard: Do you support legislation that funds abortion or people who defend them? If so, you"re pro-abortion," Saletan writes, adding, "By this standard, NRLC is against contraception" (Saletan, "Human Nature," Slate, 8/3).~ "Surgery for Seniors vs. Abortions?" Viveca Novak, FactCheck.org: An advertisement by the Family Research Council "merg[es] the fears of seniors worried about their health care with those of antiabortion advocates" by featuring an older man concerned with a federal health plan under which the government ""won"t pay for my surgery, but we"re forced to pay for abortions,"" Novak writes. However, "[n]one of the health care overhaul measures that have made it through" congressional committees "say that abortion will be covered," and "one of them explicitly says that no public funds will be used to finance the procedure," Novak writes, noting that "none of the bills call explicitly for cuts in Medicare coverage, much less rationing, under a public plan." In the blog entry, Novak examines each bill considered by Congress and how it is perceived by both sides of the abortion debate. She notes that the bills generally "leave the specifics of what medical services would be covered" to be decided by an advisory panel that would make recommendations to the HHS secretary (Novak, FactCheck.org, 7/31).Antiabortion-Rights Blog ~ "Joshua DuBois Exclusive Interview: Talking Abortion Reduction," David Brody, The Brody File: In an interview with DuBois, head of the White House Office of Faith-Based and Neighborhood P
"Senate Democrats may decide to pass a U.S. health-care overhaul without Republican support if some opposition lawmakers don"t agree to a plan by mid-September," Senator Charles Schumer[ D-N.Y.] said" according to Bloomberg. Schumer said Sen. Max Baucus, D-Mont., set a self-imposed deadline of Sept. 15 to lead a negotiating team, composed of three Republicans and three Democrats within his Finance Committee, to a bipartisan compromise.
"The White House tried Monday to douse speculation that it might raise taxes on the middle class in violation of President Obama"s campaign promise, just a day after two of his top economic advisers left the door open to such a move to rein in spiraling deficits," The New York Times reports. "Mr. Obama told his economic team in a meeting at the White House that he intended to stand by his promise not to increase taxes on families making less than $250,000, aides said."
The University of Illinois at Chicago has been awarded a $7.2 million federal grant to establish the UIC Center of Excellence in Eliminating Health Disparities.
If you are 50 or older and you break your hip, you have a one in four chance of dying within five years. Break your back, and you have a one in six chance of dying that soon, says a McMaster University study.
Statistics released yesterday by the NHS Information Centre reflect a year when dentists were working hard to make the new dental contract of 2006 work, according to the British Dental Association (BDA). The Dental Earnings and Expenses, England and Wales, 2007/08 report, which considers the earnings of dentists who undertook NHS work in England or Wales in the second year of the new contract, paints a picture of earnings settling after a transitional year in 2006/07.
Celera Corporation (NASDAQ:CRA) announced yesterday the presentation of data replicating its novel mass spectrometry-based approach to identify and validate circulating protein biomarkers that detect non-small cell lung cancer (NSCLC) in an independent cohort of individuals with lung cancer. This study was performed in collaboration with scientists at NYU Langone Medical Center, NY. A key outcome of the study was the validation of a 9 biomarker immunoassay on a cohort of samples that is enriched for stage I disease, important for screening of early stage disease. The assay detected lung cancer with 92% sensitivity at 93% specificity. The panel also accurately distinguished malignant cases from benign lung disease. The data is being presented at the 13th World Conference on Lung Cancer as part of the International Association for the Study of Lung Cancer (IASLC) in San Francisco, CA.
A blood test (BNP) should be recommended over an electrocardiogram (ECG) for the diagnosis of heart failure suggests research published by the National Institute for Health Research Health Technology Assessment (NIHR HTA) programme.
Infectious diseases are important causes of morbidity and mortality in patients with cancer. In certain cases, the malignancy itself can predispose patients to severe or recurrent infections. The National Comprehensive Cancer Network (NCCN) recognizes the importance of providing the latest information on treating these infections and has developed the NCCN Clinical Practice Guidelines in Oncology(TM) for the Prevention and Treatment of Cancer-Related Infections. The NCCN Guidelines were recently updated to include information about the effect that the H1N1 virus, or "swine flu," may have on the diagnosis and treatment of cancer treatment-related infections.
As we all know from experience, people eat not only because they are hungry, but also because the food just simply tastes too good to pass up. Now, a new study in the August 6th Cell Metabolism, a Cell Press publication, helps to explain how leptin, a hormone produced by fat tissue, influences that motivation to eat.
A new study raises the possibility that flies and other insects that encounter nanomaterial "hot spots," or spills, near manufacturing facilities in the future could pick up and transport nanoparticles on their bodies, transferring the particles to other flies or habitats in the environment. The study on carbon nanoparticles - barely 1/5,000th the width of a human hair - is scheduled for the Aug. 15 issue of ACS" Environmental Science & Technology, a semi-monthly journal.
"As if hedging their bets on health reform, Democrats are emphasizing smaller but still significant health-related investments this year, from food safety and community health centers to a greater emphasis on rooting out abuses in Medicare and Medicaid," Politico reports. "It"s a far cry from the more ambitious government-backed insurance option proposed by President Barack Obama and House Democrats. But it does add up to a major expansion of the government"s role in public health - and one that shows a greater willingness to add personnel to regulate and administer programs."
News organizations continue to cover contentious town hall meetings.
The Health and Safety Executive (HSE) is warning employers to ensure they assess the safety of equipment and ensure that it is sufficiently guarded after an employee"s left hand was severely damaged by the rotating blades of a valve that forms part of the extraction system in a metal recycling process.
In a presentation at the current General Meeting of the American Society for Microbiology (ASM) being held in Philadelphia, PA, a simple and inexpensive developmental diagnostic assay produced by MicroPhage, Inc., http://www.microphage.com, was shown to be highly accurate for rapid identification of serious staph bacterial infections from skin and soft tissue infections.