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Spike In Australian H1N1 Cases Could Lead WHO To Declare Pandemic
The H1N1 (swine flu) outbreak could soon be declared the first flu pandemic in 41 years after a recent jump in the number of confirmed cases in Australia, WHO officials said Tuesday, the AP/Google.com reports (Jordans, AP/Google.com, 6/9).
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H1N1 Could Infect Up To 2B People Within Next Two Years, WHO Says
The WHO on Friday said the "H1N1 swine-flu virus could infect up to two billion people over the next two years - about one of every three people in the world," VOA News reports. According to the news service, "A separate WHO report Friday said the virus has spread to almost every country in the world, killing about 800 people since it emerged in April" (7/25).
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Competitive Technologies' Pain Therapy Medical Device To Be Used In Independent Clinical Study
Competitive Technologies, Inc. (NYSE Amex: CTT) announced today that CTT"s pain therapy medical device will be used by clinical investigators at the Virginia Commonwealth University Massey Cancer Center for a Phase II independent clinical study. The study will examine the ability of CTT"s U.S. FDA-cleared device to decrease pain associated with chemotherapy-induced peripheral neuropathy (CIPN).
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Yale Discovery May Open Door To Drug That Cuts Appetite And Boosts Energy

In a major advance in obesity and diabetes research, Yale School of Medicine scientists have found that reducing levels of a key enzyme in the brain decreased appetites and increased energy levels. Reductions in the levels of the enzyme prolylcarboxypeptidase (PRCP) led to weight loss and a decreased risk of type 2 diabetes in mice, according to research published in the August issue of The Journal of Clinical Investigation. The team found that PRCP is located in the hypothalamus and regulates levels of a peptide known for inhibiting food intake and stimulating energy expenditure- the alpha-melanocyte stimulating hormone (alpha-MSH). Researchers found that blocking the PRCP enzyme keeps the alpha-MSH peptides from being degraded, resulting in higher levels of alpha-MSH and decreased appetite. "Our research provides the first evidence that breaking down molecules in the brain that regulate metabolism is an important component of weight control," said senior author Sabrina Diano, associate professor in the Departments of Obstetrics, Gynecology and Reproductive Sciences, and Neurobiology. "Our findings provide a possible new target for the development of drugs to control metabolic disorders such as obesity and type 2 diabetes." Diano and her team conducted the study in congenic mice that were naturally lean and later in mice that had PRCP removed. Animals without the PRCP enzyme were leaner and ate less food. They also had higher levels of alpha-MSH in the hypothalamus compared to control animals. The mice were put on a diet of 45 percent fat-the equivalent of eating fast food everyday-and even with this high fat diet, they did not gain as much weight as control animals on a regular diet. Diano said the next step is to study how PRCP is regulated. Other authors on the study include Nicholas Wallingford, Bertrand Perroud, Qian Gao, Anna Coppola, Erika Gyengesi, Zhong-Wu-Liu, Xiao-Bing Gao, Adam Diament, Kari A. Haus, Zia Shariat-Madar, Fakhri Mahdi, Sharon L. Wardlaw, Alvin H. Schmaier and Craig H. Warden. Citation: The Journal of Clinical Investigation, Vol. 119, No. 8 (August 2009) Link: Sabrina Diano Yale University


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