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Strong Immune Response To New SiRNA Drugs In Development May Cause Toxic Side Effects
Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates can also induce a strong immune response, causing toxic side effects. Understanding how siRNA stimulates this undesirable immune activity, how to test for it, and how to design siRNA drugs to avoid it are critical topics explored in a timely review article published online ahead of print in Oligonucleotides, a peer-reviewed journal published by Mary Ann Liebert, Inc.
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State Of The Air Report
The American Lung Association released its State of the Air: 2009 Report this month. The 10th annual report states that air pollution has significantly improved in some areas of the country, but major cities still have significant problems with pollutants.
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New Connection Between Cancer Cells, Stem Cells Pinpointed By Stanford Discovery
A molecule called telomerase, best known for enabling unlimited cell division of stem cells and cancer cells, has a surprising additional role in the expression of genes in an important stem cell regulatory pathway, say researchers at the Stanford University School of Medicine. The unexpected finding may lead to new anticancer therapies and a greater understanding of how adult and embryonic stem cells divide and specialize.
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When Managing Low-Risk Patients With Chest Pain In The Emergency Department, Cardiac CT Is More Cost Effective

The use of cardiac CT for low-risk chest pain patients in the emergency department, instead of the traditional standard of care (SOC) workup, may reduce a patient"s length of stay and hospital charges, according to a study performed at the University of Washington School of Medicine, Seattle, WA. The SOC workup, which is timely and expensive, consists of a series of cardiac enzyme tests, ECGs and nuclear stress testing. Fifty patients were included in the study. "We found that cardiac CT based workups in low risk chest pain patients decreased the length of hospital stay up to 20 hours and was significantly cheaper (44% less) than using the standard of care workup," said Janet May, MS, lead author of the study. "The SOC mean length of stay was 25.4 hours and the mean length of stay for cardiac CT with observation was 14.3 hours. The mean charges for SOC were $7,597; the mean charges for cardiac CT with observation were $6,153; and the mean charges for cardiac CT without observation were $4,251," said May. "Delivering care through emergency departments is expensive, so cost containment in that setting is critical. Over six million patients present to US emergency rooms each year with chest pain and up to 79% of those patients fall into the low-risk category," she said. "Our study shows that cardiac CT has the potential to significantly reduce cost and length of stay in the emergency department by rapidly identifying those patients who can safely be discharged quickly," said May. This study appears in the July issue of the American Journal of Roentgenology. Heather Curry American Roentgen Ray Society


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