DiagnosticsThe Preclinical Natural History Of Serous Ovarian Cancer: Defining The Target For Early Detection
Ovarian cancer kills approximately 15,000 women in the United States every
year, and more than 140,000 women worldwide. Most deaths from ovarian
cancer are caused by tumors of the serous histological type, which are
rarely diagnosed before the cancer has spread.
In order to better understand the early natural history and to guide rational design of an early
detection strategy for these cancers, Patrick Brown and colleagues from
Stanford
University developed models for the growth, progression, and detection of
these cancers, in order to define what properties a biomarker-based
screening test would require in order to be clinically useful.
Funding:
This work was funded by the Canary Foundation and the Howard
Hughes Medical Institute. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
Competing Interests:
The authors have declared that no competing interests
exist.
Citation:
"The Preclinical Natural History of Serous Ovarian Cancer: Defining the Target for Early Detection."
Brown PO, Palmer C (2009)
PLoS Med 6(7): e1000114. doi:10.1371/journal.pmed.1000114
PLoS Medicine