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Study Looks At HIV, Risk Behaviors Among Male Clients Of Sex Workers In Tijuana, Mexico
"A large percentage" of U.S. and Mexican men who regularly engage in sexual activity with sex workers in Tijuana, Mexico, do not use condoms and have a history of substance and alcohol use, according to a study published in the online journal AIDS, the Los Angeles Times" blog "L.A. Now" reports. The study, by researchers from Mexico and the University of California-San Diego, surveyed 400 men - both Mexico and U.S. residents - and found that half of the men had unprotected sex with a female sex worker within the last four months. Researchers noted that although Tijuana authorities require that sex workers be registered and tested regularly for HIV, "only about half of [sex workers] have registered or been tested," according to the blog. Thomas Patterson of the UC-San Diego"s department of psychiatry and the Veterans Affairs health center, said the findings indicate a need for an educational campaign targeting men who frequent sex workers (Perry, 7/11).
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The Effect Of Dietary Factors On Dementia
Experts estimate that over 24 million people worldwide suffer from dementia, and many of these people live in low- and middle-income countries. Recently, there has been growing interest in whether dietary factors, particularly oily fish and meat, might influence the onset and/or severity of dementia. Oily fish are rich in omega-3 long-chain polyunsaturated fatty acids, which some studies suggest are positively related to cognitive function in later life. Conversely, there is a suggestion from some studies that increased meat consumption may be related to cognitive decline. To examine this, a group of international researchers studied older people in 7 middle- to low-income countries. You can read the results of their study in the August 2009 issue of the American Journal of Clinical Nutrition.
News of the day
Mycamine(R) Now Available In 13 EU Markets For Treatment Of Serious Fungal Infections
MYCAMINE (micafungin), the newest echinocandin, is now available in thirteen European markets: UK, Greece, Czech Republic, Slovakia, Nordic region*, Spain, Germany, Ireland and France following its EU approval in April 2008.
Medical Devices

Sutent Significantly Improved Progression-Free Survival For Patients With Advanced Pancreatic Islet Cell Tumours

Pfizer announced preliminary results from a randomized Phase 3 trial of Sutent (sunitinib malate) in patients with advanced pancreatic islet cell tumours, also known as pancreatic neuroendocrine tumours, which is a different type of cancer than the more common pancreatic adenocarcinoma. Study findings demonstrated that median progression-free survival (PFS) was 11.1 months in patients treated with Sutent compared to 5.5 months in patients treated with placebo. Researchers today presented these data at the 11th World Congress on Gastrointestinal Cancer in Barcelona, Spain. The independent Data Monitoring Committee (DMC) recommended halting the trial earlier this year because Sutent showed significant benefit and the study had met its primary endpoint. Full analysis of the data is ongoing. "In this study, Sutent demonstrated an impressive improvement in progression-free survival for patients with pancreatic islet cell tumours," said Dr. Eric Raymond, MD, PhD, Professor of Medical Oncology and Head of University Department of Medical Oncology (Service Inter Hospitalier de Cancerologie) Bichat-Beaujon, Clichy, France, and lead investigator on this sunitinib Phase 3 study. "This is encouraging news for patients, especially given that there are limited treatment options for this type of advanced cancer." Phase 3 Trial Results This international, Phase 3 trial compared sunitinib to placebo in patients with progressive, well-differentiated, malignant pancreatic islet cell tumours who had progressed in the last 12 months. Patients were randomized to either the sunitinib (n=75) (37.5 mg/day, continuous daily dosing) plus best supportive care arm or the placebo plus best supportive care arm (n=79). Results showed that median PFS was 11.1 months in patients treated with sunitinib compared to 5.5 months in patients treated in the placebo arm (Hazard ratio 0.397, pAbout Pancreatic Islet Cell Tumours In contrast to exocrine pancreatic adenocarcinoma, pancreatic islet cell tumours are rare, indolent tumours of the endocrine pancreas with an incidence of two to four people per million annually worldwide. Pancreatic islet cell tumours include insulinomas, glucagonomas and gastrinomas. Current treatment options are limited. About Sutent(®) (sunitinib malate) Sutent, an oral multi-kinase inhibitor, is currently approved for both advanced renal cell carcinoma (RCC) and second-line gastrointestinal stromal tumour (GIST), based on efficacy and safety data from large, randomized Phase 3 clinical trials. Sutent works by blocking multiple molecular targets implicated in the growth, proliferation and spread of cancer. Two important Sutent targets, vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR), are expressed by many types of solid tumours and are thought to play a crucial role in angiogenesis, the process by which tumours acquire blood vessels, oxygen and nutrients needed for growth. Sutent also inhibits other targets important to tumour growth, including KIT, FLT3 and RET. Important Sutent(®) (sunitinib malate) Safety Information Women of child bearing age who are (or become) pregnant during therapy should be informed of the potential for foetal harm while on Sutent. Decreases in left ventricular ejection fraction (LVEF) to below the lower limit of normal (LLN) have been observed. Patients with concomitant cardiac conditions should be carefully monitored for clinical signs and symptoms of congestive heart failure. Patients should be monitored for hypertension and treated as needed with standard antihypertensive therapy. Complete blood counts (CBCs) with platelet count and serum chemistries should be performed at the beginning of each treatment cycle for patients receiving treatment with Sutent. The most common adverse reactions in advanced RCC and GIST clinical trials were fatigue, asthenia, diarrhea, nausea, mucositis/stomatitis, ONC09/010 vomiting, dyspepsia, abdominal pain, constipation, hypertension, rash, hand-foot syndrome, skin discoloration, altered taste, anorexia and bleeding. Pfizer Oncology


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