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Revealing Leukemia-Initiating Cells
Two new studies reveal a way to increase the body"s appetite for gobbling up the cancer stem cells responsible for acute myeloid leukemia (AML), a form of cancer with a particularly poor survival rate. The key is targeting a protein on the surface of those cells that sends a "don"t eat me" signal to the macrophage immune cells that serve as a first line of defense, according to the reports in the July 24th issue of the journal Cell, a Cell Press publication.
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Drug Companies Increasingly Use Medical Science Liaisons
The Wall Street Journal reports that drug companies are increasingly using medical science liaisons: "Pharmaceutical companies are barred by the Food and Drug Administration from promoting unapproved drug uses, called off-label use, but they are using employees called "medical science liaisons," who are often physicians and pharmacists, as a legal way to discuss those uses. Medical science liaisons, who are considered medical rather than sales staff, have greater freedom than salespeople as they visit doctors offices to discuss the science behind a medicine, including unapproved uses." It notes: "The FDA requires traditional sales reps to refer information requests to their employers" medical or scientific staff, MSLs are usually on those staffs."
News of the day
Results From A European Caregiver Survey Highlight The Impact Of Attention Deficit Hyperactivity Disorder (ADHD) On The Child And The Family
Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, today announced results of a European survey that found a child"s Attention Deficit Hyperactivity Disorder (ADHD) symptoms at school were a key concern for parents, yet outside of school their child"s ADHD also had significant impact on parents" personal time.1 The survey also revealed key findings surrounding parents" role in assessment and treatment for their child.1 Additionally, the survey suggested that informational needs may not be met adequately for these children with ADHD and their families.1 Conducted in partnership with ADHD advocacy groups in four EU countries, the survey analysed parental impressions surrounding the impact of ADHD on their child, themselves and their family, as well as their child"s ADHD treatment plan.
Diagnostics

Risk Factors Of Cardiovascular Disease Rising In Poor, Young

Cardiovascular disease is increasing in adults under 50 and those of lower socioeconomic status, despite recent trends which show that cardiovascular disease is declining in Canada overall, say researchers at the Peter Munk Cardiac Centre. Untreated cardiovascular disease can lead to heart failure, coronary artery disease and death, and is the most common cause of hospitalization in North America. By exploring national trends in heart disease, hypertension, diabetes, obesity and smoking prevalence from 1994-2005, researchers found that cardiovascular disease is on the rise in adults under 50 and those of lower socioeconomic status according to a study published in the July edition of the Canadian Medical Association Journal. "Our results indicate that young people are increasingly bearing the burden of cardiovascular risk factors," says Dr. Douglas Lee, cardiologist and scientist at the Institute for Clinical Evaluative Sciences (ICES). "This is an important group because they are the ones who will predict future heart disease, and earlier onset of cardiovascular disease means potentially longer and more intense treatment over their lifetime." The study, called "Trends in risk factors for cardiovascular disease in Canada: temporal, socio-demographic and geographic factors," sampled Canadians aged 12 years and older from all socioeconomic and ethnic groups. The prevalence of heart disease and diabetes is rising fastest among Canadians of lower socioeconomic status, who also tend to have the highest cardiovascular risk profiles. The prevalence of hypertension and obesity is increasing in nearly all Canadians, but is rising fastest in those with higher incomes. "These trends are quite different from the United States where some risk factors such as hypertension are declining," Dr. Lee continues. "In Canada risk factors have not reached a plateau, suggesting that these increases may continue to worsen over time." These findings have implications on both the policy and individual level. Increasing community programming for physical activity in poorer areas, making cities more pedestrian-friendly and improving healthy eating habits are ways to encourage healthier lifestyles and potentially decrease the rising prevalence of risk factors. Young individuals who haven"t considered themselves at risk should take action to reduce their risk of developing cardiovascular disease by diligently scheduling routine medical exams and talking to their doctor. The Canadian Institute of Health Research (CIHR) and Heart and Stroke Foundation funded this study. Peter Munk Cardiac Centre


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