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Exelixis Reports Encouraging Phase 1 Data To Be Presented At ASCO For XL228, A Multi-Targeted Inhibitor Of Key Cancer Signaling Kinases
Exelixis, Inc. (Nasdaq: EXEL) today reported encouraging data from an ongoing Phase 1 dose-escalation trial of XL228 in patients with advanced malignancies. XL228 is a small molecule inhibitor of insulin-like growth factor type 1 receptor (IGF1R), SRC, Aurora kinases, and fibroblast growth factor receptor types 1, 2, and 3 (FGFR1-3), which are associated with cancer cell proliferation, survival, and metastasis. The compound also inhibits BCR-ABL, including the T315I mutant form which is resistant to currently approved inhibitors. David Smith, MD, Professor of Medicine at the University of Michigan, an investigator on the Phase 1 trial, will present the data in an oral session (Abstract #3512) beginning at 4:15 p.m. local time on Saturday, May 30, 2009, at the American Society of Clinical Oncology Annual Meeting, which is being held May 29-June 2 in Orlando.
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Pharmaceutical Society of Australia Welcomes New Health Portfolio

The announcement of the establishment of a new Indigenous Health, Rural and Regional Health and Regional Services Delivery portfolio has been welcomed by the Pharmaceutical Society of Australia. President of the PSA, Warwick Plunkett, said the establishment of the new portfolio was recognition of the unique and challenging issues faced by indigenous health consumers as well as those living in non-urban areas of Australia. "Often people living in rural, regional and remote areas of Australia face enormous difficulties when it comes to their health-care needs," Mr Plunkett said. "In addition, indigenous health has its own unique challenges which the establishment of this portfolio will go a long way towards addressing. "The PSA, as the organisation that represents the professional interests of pharmacists across the nation, is well aware of these difficulties and has long advocated policies and programs to help address them. "The establishment the Indigenous Health, Rural and Regional Health and Regional Services Delivery portfolio gives the Government and health-care professionals in Australia a vehicle from which to work to improve the health needs and outcomes of indigenous Australians and those living in non-urban areas." Mr Plunkett said the appointment of Mr Warren Snowdon as Minister for Indigenous Health, Rural and Regional Health and Regional Services Delivery underscored the importance of the portfolio. "Mr Snowdon is a widely experienced politician and as a member for a rural area has first-hand knowledge and experience of some of the issues and difficulties faced by consumers in these areas," Mr Plunkett said. "On behalf of the PSA, I congratulate Mr Snowdon on his appointment and look forward to working closely with him and his new department to help achieve the outcomes that people in these areas so demonstrably need." Pharmaceutical Society of Australia


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