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First Ten-Year Follow-Up Shows That Treatment With AVONEX® Leads To Long-Term Benefits In Early Multiple Sclerosis Patients
Biogen Idec (NASDAQ: BIIB) announced data results from the CHAMPIONS (Controlled High-Risk AVONEX® (interferon beta-1a) Multiple Sclerosis (MS) Prevention Study In Ongoing Neurologic Surveillance) study, an open label follow-up to CHAMPS (Controlled High Risk Subjects AVONEX MS Prevention Study). Based on the CHAMPS study, AVONEX was granted approval for use in patients who experienced their first clinical MS episode with MRI findings. The CHAMPIONS ten-year follow up showed that patients treated immediately after their first episode had significantly less chance of experiencing a second attack versus those patients with delayed treatment. These results at ten years also indicate that 80 percent of patients taking AVONEX were below an expanded disability status scale (EDSS) score of three. These data were presented as a poster at the Annual American Academy of Neurology (AAN) meeting.
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White House Budget Chief Says Issue Of Abortion Coverage In Health Reform Still Under Debate
In an appearance on "Fox News Sunday," White House Office of Management and Budget Director Peter Orszag said that he is "not prepared to say explicitly" whether health care reform legislation would prohibit the use of federal tax revenue to fund abortion coverage, the New York Times reports. Orszag"s statement came in reply to a question asking whether he was prepared to say that "no taxpayer money will go to pay for abortions." Orszag said, "It"s obviously a controversial issue, and it"s one of the questions that is playing out in the debate" (Pear/Liptak, New York Times, 7/20).Sen. Judd Gregg (R-N.H.), who also appeared on "Fox News Sunday," said, "No matter what your views are on abortion, you shouldn"t ask people to use their tax dollars if they think that abortion is taking a life." Gregg added, "I would hate to see the health care debate go down over that issue. We do really need health care reform, and it has to be substantive. ... So hopefully we won"t get ourselves wrapped around the wheel of abortion in this debate" (FoxNews.com, 7/19). According to the Times, there is an ongoing behind-the-scenes debate over handling abortion coverage in health overhaul legislation. The debate affects both the public insurance plan the legislation would create and private insurers, who would receive tens of billions of dollars in federal subsidies to expand coverage for low- and moderate-income U.S. residents. A provision in the House health reform bill (HR 3200) calls for a federal advisory committee to advise the HHS secretary on an "essential benefits package" that most insurers would be required to provide. Abortion-rights opponents want abortion coverage excluded from the package, while abortion-rights advocates say the decision should be left to medical professionals. House committees working on health reform legislation have rejected Republican amendments that would have restricted abortion coverage. The Hyde Amendment, first enacted in 1976, prohibits the use of federal Medicaid money for abortion services. However, abortion-rights opponents argue that federally subsidized coverage of the uninsured would not be subject to the existing restrictions. The National Right to Life Committee issued an analysis of the House bill, stating, "There is no doubt that coverage of abortion will be mandated, unless Congress explicitly excludes abortion from the scope of federal authority to define "essential benefits."" According to the group, even if the HHS secretary did not require abortion coverage, "federal courts would interpret the broadly worded mandatory categories of coverage to include abortion" (New York Times, 7/20).
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Rapid Methods To Detect Microorganisms In Food: K-State To Host Workshop
Kansas State University once again is host to a noted microbiology workshop that helps the scientists who test food and other samples for microorganisms. K-State"s 29th annual Rapid Methods and Automation in Microbiology workshop will be June 19-26.
Endocrinology

Nox(4)ious Requirement In Common Infant Tumor

Hemangiomas are the most common tumor of infancy. They are benign tumors derived from cells that line blood vessels (endothelial cells) and spontaneously regress as a child gets older. Jack Arbiser and colleagues, at Emory University School of Medicine, Atlanta, have now provided new insight into the molecules that control hemangioma growth and found that inhibiting a key molecule substantially inhibits hemangioma growth in a mouse model. Specifically, the protein Nox4 was found to be crucial for hemangioma growth in a mouse model and the drug fulvene 5 was found to be a potent in vitro inhibitor of Nox4 and to substantially inhibit in vivo hemangioma growth. The authors therefore suggest that targeting Nox4, potentially using fulvene derivatives, might provide a way to attenuate hemangioma growth. Title: Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice https://www.the-jci.org/article.php?id=33877 Author: Jack L. Arbiser Emory University School of Medicine, Atlanta, Georgia, USA. Karen Honey Journal of Clinical Investigation


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