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Human Genome Sciences Submits Biologics License Application To FDA For ABthrax(TM)
Human Genome Sciences, Inc. (Nasdaq: HGSI) announced that it has submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for its human monoclonal antibody drug ABthrax(TM) (raxibacumab) for the treatment of inhalation anthrax.
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Team Preop Briefing Improves Communication, Reduces Errors
A short, preoperative team briefing prior to cardiac surgery - where each person on the team speaks - improves communication and reduces errors and costs, according to a pilot study conducted at Mayo Clinic.
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Treating Lung Cancer With Vandetanib Shows Clinical Benefit When Combined With Docetaxel
When combined with standard chemotherapy, an international Phase III trial has shown that the oral targeted therapy vandetanib improves progression-free survival for patients with advanced non-small cell lung cancer, according to research from The University of Texas M. D. Anderson Cancer Center.
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Non Invasive Assessment Of Treatment For Common Type Of Breast Cancer

Non-invasive imaging can measure how well patients with the most common form of breast cancer - estrogen receptor positive type - respond to standard aromatase inhibitor therapy after only two weeks and shows similar findings that more invasive needle sampling identifies, according to a poster presentation to be presented at the ASCO annual meeting May 29 - June 2, 2009, Orland, Fl. Using Positron Emission Tomography (PET) scanning and a glucose analogue called FDG, a research team led by Hannah Linden, M.D. and David Mankoff M.D., of the Seattle Cancer Care Alliance and the University of Washington, scanned 21 patients before and after two weeks of aromatase inhibitor therapy. Many of the patients also underwent a needle biopsy as a control measure to compare the two techniques. The results - 16 of the 21 patients had a greater than 20 percent decline in FDG values - "paralleled perfectly" earlier work done by UK-based researchers who used needle biopsies to measure whether the proliferation of cancer cells was slowed by therapy, according to Linden, who is a breast cancer oncologist. "Our findings are exciting because they suggest that we can measure a patient"s response to therapy noninvasively, and PET scanning provides us simultaneous quantitative metabolic measurements at multiple tumor sites," Linden said. "PET has the potential to be a powerful tool to help doctors make important treatment decisions in as little as two weeks instead of two or more months." It"s common for patients with estrogen receptor positive cancer to a bone-dominant type yet they have remained largely unstudied in clinical trials because they are very difficult to image, according to Linden. "Our work allowed us to study a common problem in a way that"s not been done before and to help more people," she said. "More work needs to be done but in my mind this was a homerun," Linden said. The study was funded by a "Progress for Patients" grant from the National Cancer Institute and the Avon Foundation. Joining Linden were researchers from the University of Washington, Fred Hutchinson Cancer Research Center and the University of Arizona Cancer Center. http://www.asco.org/ASCOv2/Meetings/ASCO+Annual+Meeting Dean Forbes Fred Hutchinson Cancer Research Center


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