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Fate Therapeutics To Present Data On Stimulation Of Osteogenic Activity Using Small Molecule Modulators Of Wnt Pathway
Fate Therapeutics, Inc. announced the presentation of data from its research on small molecule modulators of the Wnt pathway for osteo-regeneration at the 7th Annual Meeting of the International Society for Stem Cell Research (ISSCR) in Barcelona, Spain. In its findings, the Company demonstrated that selected Wnt activators induce the differentiation of mesenchymal stem cells to mature, bone-forming osteoblasts. The study highlights the potential for using small molecule Wnt activators as osteogenic agents. Because osteogenic agents stimulate positive bone growth, they may offer an improved course of action in clinical settings ranging from orthopedics to osteoporosis as compared to current medications aimed at preventing bone decay.
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Celera Presents Data Replicating Its Immunodiagnostic Assay To Detect Lung Cancer From Blood Serum
Celera Corporation (NASDAQ:CRA) announced yesterday the presentation of data replicating its novel mass spectrometry-based approach to identify and validate circulating protein biomarkers that detect non-small cell lung cancer (NSCLC) in an independent cohort of individuals with lung cancer. This study was performed in collaboration with scientists at NYU Langone Medical Center, NY. A key outcome of the study was the validation of a 9 biomarker immunoassay on a cohort of samples that is enriched for stage I disease, important for screening of early stage disease. The assay detected lung cancer with 92% sensitivity at 93% specificity. The panel also accurately distinguished malignant cases from benign lung disease. The data is being presented at the 13th World Conference on Lung Cancer as part of the International Association for the Study of Lung Cancer (IASLC) in San Francisco, CA.
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A Novel Marker Of Colorectal Carcinoma
Colorectal cancer is thought to result from a combination of environmental factors: diet, lifestyle, chronic inflammation and accumulation of specific genetic alterations. The pathogenesis and development of colorectal cancer involves multi-genes and multi-steps. TSPAN1 (GenBank Accession No. AF065388) is a new member of TM4SF located at chromosome 1 p34.1. It encodes a 241 amino acid protein. TSPAN1 was reported as a tumor-related gene recently.
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New Treatment Method Reduces Pain And Increases Mobility In Patients With Vertebral Compression Fractures

Vesselplasty, a new minimally invasive procedure, increases mobility and reduces pain and the need for pain killers in patients with vertebral compression fractures (VCFs), according to a study performed at the Hospital Universitario Doctor Peset, Valencia, Spain. Vesselplasty is a new alternative to vertebroplasty and kyphoplasty-two conventional VCF treatment methods. Vesselplasty solves the problem of leakage of cement out of the vertebral body which can happen during both vertebroplasty and kyphoplasty," said Lucia Flors, MD, lead author of the study. The study included 29 patients with VCFs who underwent vesselplasty. "After the procedure, all patients had improvements in their pain scores; 93% of patients had improvements in mobility; and 62% of patients had a decreased need for pain killers," said Dr. Flors. There was no evidence of clinical complications following the procedure. "Vertebral compression fractures often cause severe, disabling pain and progressive deformities of the spine in osteoporotic patients," she said. "Vesselplasty is a safe alternative in the treatment of VCFs. It is an image-guided procedure that only requires conscious sedations and local anesthesia. Most patients refer improvement in their level of pain immediately following the procedure," said Dr. Flors. This study appears in the July issue of the American Journal of Roentgenology. Click here for abstract. The American Roentgen Ray Society


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