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Argenta Discovery Announces Entry Into Phase I For First Candidate From Collaboration With AstraZeneca To Develop Improved Inhaled Bronchodilators
Argenta Discovery Limited, the respiratory drug discovery and development company, announces a major milestone in its joint programme with AstraZeneca aimed at identifying improved inhaled bronchodilators to treat chronic obstructive pulmonary disease (COPD).
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SPECT MPI With Cardiolite(R) Used In BARI 2D Study To Evaluate Type 2 Diabetes And Coronary Artery Disease Treatment Strategies
Lantheus Medical Imaging, Inc., a worldwide leader in diagnostic imaging, announced today that the company"s leading imaging agent, Cardiolite® (Kit for the Preparation of Technetium Tc99m Sestamibi for Injection), was used in a recently completed five-year study examining appropriate treatment regimens for patients with type 2 diabetes and coronary artery disease. The results of this study, known as The Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D), will be presented by the University of Pittsburgh Graduate School of Public Health at a special symposium on Sunday, June 7, 2009, from 4:15 p.m. - 5:15 p.m. (CT) at the American Diabetes Association 69th Scientific Sessions in New Orleans.
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GOP Returns Fire On Comp Effectiveness, Health Reform
"GOP Senate Leader Mitch McConnell, Ky., GOP Senate Whip Jon Kyl, Ariz., Senate Republican Conference Chairman Lamar Alexander, Tenn., and House Republican Conference Chairman Mike Pence, Ind., went on the offensive following Obama"s speech in Chicago to the American Medical Association. Kyl and McConnell unveiled a bill to rival the Democratic bill, while Alexander and Pence spoke to reporters," according to the Hill. "Pence, who said he did not watch Obama"s speech, said House Republicans would try to force amendments to the bill and would vote "no" on the bill otherwise because it improperly pits the government against private insurers. He and Alexander both said such a government role would eventually prompt employers to reduce the plans they offer employees."
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Extracorporeal Shock Wave Therapy For The Treatment Of Chronic Pelvic Pain Syndrome In Males: A Randomised, Double-Blind, Placebo-Controlled Study

UroToday.com - At a glance one could assume that this study was solely empirical - on the contrary! Shock waves (SWs) seem to have a greater therapeutic potential than is assumed and understood today. Finally, the effect of SW cannot be explained by current models of thinking. The recently published SW model by Wess1 is a very promising and tremendous basic approach: SW could modify brain processes and pain storage patterns - both to be influenced therapeutically. We are going to follow these concepts by specific research investigating processes inside the brain during SW application. Possible reactions in the brain and changes under running Extracorporeal Shock Wave Treatment (ESWT) are presently the most promising approaches to understanding the working mechanisms of SW. We intend to apply SWs not only clinically, but also to enhance our knowledge by basic research about their therapeutic effects. The missing animal model for chronic pelvic pain syndrome (CPPS) does not contribute to simplifying the understanding of pathophysiological processes influenced by ESWT, in particular due to the fact that the knowledge about CPPS pathophysiology itself is very limited. Alteration in local perfusion is one more explanation for SW effects: We know that perfusion increases immediately after SW application. As a long-term effect, the VEGF expression in treated tissue increases. There are very conclusive investigations on ischemic heart tissue in which processes of neovascularisation have been induced by ESWT and consecutive VEGF increase. Whether there is a link from increased perfusion to pain relief is, however, still unclear. Based on most recent in vitro research we could imagine also extending this treatment to chronic bacterial prostatitis. The rationale could be several investigations proving the bactericide effects of SW. The in vitro findings could be linked with clinical effects and results in this group of patients who are still a therapeutic (and personal!) challenge to us urologists. Finally, ESWT is a typical outpatient therapy that can be offered very easily in private offices. Unfortunately, there is no reimbursement by public health services either in Germany or in Austria at the moment. Therefore, the incentive for urologists to apply ESWT for CPPS in their private offices is low. Additionally, many urologists are not aware of the fact that SW does not inevitably mean stone therapy, therefore equating to destruction. In fact, SWs have clearly shown tissue-regenerating effects. These effects are successfully used for the treatment of disorders of local perfusion, wound and fracture healing and even for cellulite. This fact must enter into urologists` awareness and the therapeutic potential of ESWT has to be understood. As a result of these changes, hopefully more urologists will consider this treatment as a viable option and recommend it to their CPPS patients. Reference: 1. Wess OJ, A neural model for chronic pain and pain relief by extracorporeal shock wave treatment. Urol Res. 2008 Dec;36(6):327-34. Written by Reinhold Zimmermann, MD as part of Beyond the Abstract on UroToday.com UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice. To access the latest urology news releases from UroToday, go to: www.urotoday.com Copyright © 2009 - UroToday


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