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First Ten-Year Follow-Up Shows That Treatment With AVONEX® Leads To Long-Term Benefits In Early Multiple Sclerosis Patients
Biogen Idec (NASDAQ: BIIB) announced data results from the CHAMPIONS (Controlled High-Risk AVONEX® (interferon beta-1a) Multiple Sclerosis (MS) Prevention Study In Ongoing Neurologic Surveillance) study, an open label follow-up to CHAMPS (Controlled High Risk Subjects AVONEX MS Prevention Study). Based on the CHAMPS study, AVONEX was granted approval for use in patients who experienced their first clinical MS episode with MRI findings. The CHAMPIONS ten-year follow up showed that patients treated immediately after their first episode had significantly less chance of experiencing a second attack versus those patients with delayed treatment. These results at ten years also indicate that 80 percent of patients taking AVONEX were below an expanded disability status scale (EDSS) score of three. These data were presented as a poster at the Annual American Academy of Neurology (AAN) meeting.
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Quintiles Increases Capacity To Manage Clinical Studies For Diseases Including Malaria, HIV And Tuberculosis
To improve efficiency and expand capacity to monitor the growing number of clinical studies being conducted in Western Sub-Saharan Africa, Quintiles today announced the opening of a new office in Accra, Ghana.
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Risk Factors Of Cardiovascular Disease Rising In Poor, Young
Cardiovascular disease is increasing in adults under 50 and those of lower socioeconomic status, despite recent trends which show that cardiovascular disease is declining in Canada overall, say researchers at the Peter Munk Cardiac Centre. Untreated cardiovascular disease can lead to heart failure, coronary artery disease and death, and is the most common cause of hospitalization in North America.
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Early Failure Of Knee Replacements

This study investigated a series of Kinemax knee replacements where the survival rate was only 75% at nine years, compared with previously recorded rates of 96% over ten years and tried to ascertain the reason for the significantly lower survival rate. The authors discovered that on revision "the most striking feature was polyethylene wear" on the implant and therefore undertook to have the removed implants independently anaylsed for abnormalities. The findings of scanning the implants using electron microscopy were type 2 fusion defects in the polyethylene, indicating incomplete boundary fusion. Therefore, the authors "consider that the failure of the Kinemax implants in our cohort was due to material failure of the UHMWPE, probably at the time of manufacture, exacerbated by post-manufacturing oxidation". Read the full text article. The Journal of Bone and Joint Surgery


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