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Internists Note 'Close Alignment' With Policies In America's Affordable Health Choices Act Of 2009
The president of the American College of Physicians (ACP) told the chairmen of the House Ways and Means, Energy and Commerce, and Education and Labor Committees that America"s Affordable Health Choices Act of 2009, H.R. 3200, is "closely aligned" with ACP policies on coverage, workforce, and payment and delivery system reform.
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Protein Level May Serve As Predictor Of Severe Osteoarthritis
Osteoarthritis (OA), the most common joint disorder throughout the world and a leading cause of disability, is characterized by pain, impaired joint mobility, reduction of muscular strength and loss of joint function. Unlike most other common diseases, little is known about its origins, and factors predicting a severe disease course have not been identified. A new study, the first to establish a laboratory marker for the risk of severe OA, found that vascular cell adhesion molecule 1 (VCAM-1), was a strong predictor of hip and knee joint replacement due to severe OA. The study was published in the August issue of Arthritis & Rheumatism .
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Metastatic Melanoma PV-10 Trial Results Encouraging Says Drug Company
Early results of a clinical trial that treated 40 patients with metastatic melanoma using PV-10, a form of the staining compound better known as
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Early Failure Of Knee Replacements

This study investigated a series of Kinemax knee replacements where the survival rate was only 75% at nine years, compared with previously recorded rates of 96% over ten years and tried to ascertain the reason for the significantly lower survival rate. The authors discovered that on revision "the most striking feature was polyethylene wear" on the implant and therefore undertook to have the removed implants independently anaylsed for abnormalities. The findings of scanning the implants using electron microscopy were type 2 fusion defects in the polyethylene, indicating incomplete boundary fusion. Therefore, the authors "consider that the failure of the Kinemax implants in our cohort was due to material failure of the UHMWPE, probably at the time of manufacture, exacerbated by post-manufacturing oxidation". Read the full text article. The Journal of Bone and Joint Surgery


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