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American Society Of Hematology Awards Grants To Encourage Novel Medical Training Programs
The American Society of Hematology (ASH) announces that Ellis J. Neufeld, MD, PhD, of Harvard Medical School, Thomas Shea, MD, of University of North Carolina at Chapel Hill, and Alvin Schmaier, MD, of Case Western Reserve University in Cleveland, will each receive ASH"s Alternative Training Pathway Grant this July. The grant is awarded to selected training program directors to encourage the development and implementation of novel hematology-related training programs in recognition of the need for more clinicians and clinical/translational researchers in hematology-related disciplines.
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National Organization For Rare Disorders To Honor Rare Disease Pioneers
The National Organization for Rare Disorders (NORD) will honor a senior U.S. Senator, a top Administration official, a cutting-edge television network, and several pioneering companies developing treatments for rare diseases at the 2009 NORD Gala at the National Press Club in Washington, DC, on Thursday, May 14.
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Conservative Groups Outline Strategies To Challenge Potential Supreme Court Nominees
The New York Times reports that it has obtained 10 memorandums prepared by conservative groups on President Obama"s possible choices to replace retiring Supreme Court Justice David Souter that outline how conservatives hope to frame the coming nomination debate. The memos focus on 10 female potential nominees. Although the groups have gathered information on about three dozen people, both liberals and conservatives expect that Obama will nominate a woman for the position.The memos analyze the possible nominees" records and dissect statements they have made that conservative groups find objectionable. The memorandum on Judge Diane Wood criticizes her as an "outspoken" supporter of "abortion, including partial-birth abortion." In addition, the memo on Judge Sonia Sotomayor says she is willing to expand rights in the Constitution past where the text allows, while the summary on Judge Kathleen Sullivan says she supports same-sex marriage.According to the Times, conservatives have acknowledged that Democrats" control of the Senate gives them little chance of defeating the nomination, but they still aim to mount a formidable debate. Conservative groups hope that rallying their supporters behind a common cause "could help refill depleted coffers and galvanize a movement demoralized by Republican electoral defeats," the Times reports. Gary Marx, executive director of the conservative Judicial Confirmation Network, said that donors have committed to contributing millions of dollars for advertisements on television, radio and the Internet. Richard Viguerie, a conservative fundraiser, said, "It"s an immense opportunity to build the conservative movement and identify the troops out there." Nan Aron, president of the liberal Alliance for Justice, said, "I think the mood and the politics of the country have passed [conservatives] by." According to the Times, liberal groups also have created a shared research pool for the coming debate (Savage, New York Times, 5/17).
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Early Detection Of Osteoarthritis In Dogs Could Open Doors For A Cure

Osteoarthritis is commonly diagnosed in the late and irreversible stages, when treatment can only be expected to decrease pain and slow progression of disease. Because osteoarthritis is a widespread problem in dogs, horses and humans, doctors and veterinarians need a precise way to diagnose the disease early and accurately. Now, University of Missouri researchers are investigating potential biomarkers in dogs for early diagnosis of osteoarthritis, which could help identify patients at increased risk of developing osteoarthritis. "By developing methods for earlier diagnosis of osteoarthritis, prevention or even curative treatment strategies to manage the disease become more realistic," said James Cook, professor of veterinary medicine and surgery, and the William & Kathryn Allen Distinguished Professor in Orthopedic Surgery. "Biomarkers could detect the disease before pain and swelling occurs, and owners could take preventative measures, such as modifying activities or diet, helping their pets lose weight and strengthen their joints, to reduce the likelihood of their dogs developing osteoarthritis." In the study, researchers examined potential biomarkers in synovial fluid. Synovial fluid, which is fluid that lubricates the joints, is known to have sensitive and rapid responses to joint injury. Taking samples from dogs, researchers found that synovial fluid quantity and quality were altered in injured stifle joints (the joint in the hind limbs of dogs that is the equivalent joint to the human knee). "At the MU Comparative Orthopaedic Laboratory, we are particularly interested in identification and validation of biomarkers that can detect early stages of osteoarthritis to provide accurate diagnostic and prognostic information prior to the onset of clinical disease for people and for pets," Cook said. "Our team, led by Drs. Kuroki, Stoker and Garner, is making tremendous progress in developing simple tests on blood, urine and synovial fluid that show great promise for helping us diagnose impending osteoarthritis before it is too late to help the patient in the most effective manner." Osteoarthritis causes degradation of articular cartilage, leading to pain, inflammation and loss of motion in the joint. Veterinarians predict that 20 percent of middle-aged dogs and 90 percent of older dogs have osteoarthritis in one or more joints and the percentages are even higher for the human population. The study, "Examination of Synovial Fluid Hyaluronan Quantity and Quality in Stifle Joints of Dogs with Osteoarthritis," was published in the American Journal of Veterinary Research. It was coauthored by Cook; Rachel Venable, doctoral student; Aaron Stoker, research assistant professor; Cristi Cook, clinical assistant professor; and Mary Cockrell, research specialist. Kelsey Jackson University of Missouri-Columbia


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