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Serum Bile Acid Profiling For Inflammatory Bowel Disease Characterization
Based on serum bank material, BA profiling was applied in IBD patients and healthy controls which showed that most but not all BA species were decreased to a different extent in CD and UC. BA decreases were highly pronounced in CD patients with surgical interventions in the gut. On the other hand, UC patients with additional liver and gallbladder diseases showed clearly increased levels of those BAs that are synthesized directly in the liver (primary BAs), or subsequently modified by intestinal bacteria (secondary BAs). Furthermore, a marked decrease in the toxic BA lithocholic acid (LCA) was found together with a marked increase in its physiological detoxification product, hyodeoxycholic acid (HDCA), irrespective of the IBD phenotype or clinical manifestation, which showed accelerated detoxification activity in IBD patients. Thus, serum BA profiling might serve as an additional diagnostic tool for IBD characterization and differentiation. In combination with expression profiles of nuclear pregnane X receptor (PXR)-regulated genes, it might allow us to estimate the BA detoxification potential of IBD patients.
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Pre-Diabetes Costs Nation $25 Billion Annually In Extra Medical Care, New Data Show
One of every four American adults suffers from a silent condition known as pre-diabetes at a cost of more than $25 billion a year in increased medical costs, according to new data published today. And among the 180,000 pregnant women diagnosed with gestational diabetes, health care costs attributed to the condition are estimated at $623 million a year, a companion study showed.
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Researchers Compare Different Systems Of Measuring Treatment Intensity In Hypertension Care
It is known that more intensive management of hypertension can improve blood pressure control and thus improve cardiovascular outcomes. However, there are several different systems of measuring the intensity of management of hypertension, and they have not been previously compared. If one system performs best, it would be important to use it to measure intensity of management for research and quality improvement purposes. Researchers from Boston University have compared different measures of treatment intensity in hypertension care and have found that one of the measures should be preferred to the others. This study, which appears in the July issue of Circulation: Cardiovascular Quality and Outcomes, shows that the measure originally described by Okonofua, et al. (Hypertension, 2006) predicts blood pressure control more effectively than the other two measures studied.
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Burgess Accepts President Obama's Offer To Meet And Discuss Health Reform Bill

Congressman Michael C. Burgess, M.D. (R-Texas) sent a letter to President Obama yesterday accepting his invitation to "come over to the White House and go over line-by-line" the health care reform plan the President is pushing. Last week President Obama held a health care town hall meeting in North Carolina, and offered the invitation to Members of Congress. President Obama stated, "When we come back in September, I will be available to answer any questions that members of Congress have. If they want to come over to the White House and go over line-by-line what"s going on, I will be happy to do that." In his letter to President Obama, Burgess accepts the President"s invitation and states that, as a doctor, he has several concerns with the plan and also many ideas he believes he and the President can both agree on when it comes to health reform. The Office of Congressman Michael C. Burgess, M.D


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